Terminal acute myelogenous leukemia in a patient with congenital agranulocytosis.

Wong, W Y; Williams, D; Slovak, M L; Charak, B; Mazumder, A; Snyder, D; Powars, D R; Brynes, R K

Wong, W Y; Williams, D; Slovak, M L; Charak, B; Mazumder, A; Snyder, D; Powars, D R; Brynes, R K.

Afiliación

Wong WY; Department of Pediatrics, University of California, Los Angeles.

Am J Hematol ; 43(2): 133-8, 1993 Jun.

Article en En | MEDLINE | ID: mdl-8342541

RESUMEN

Congenital agranulocytosis terminating in acute myelogenous leukemia has been previously reported in only two cases of adolescent males. We describe the clinical and laboratory features of a 13-year-old male with congenital agranulocytosis, treated with G-CSF with initial good neutrophil response, who subsequently developed acute myeloid leukemia. This rare complication may define a preleukemic subset of patients for whom G-CSF therapy is ineffective. The diagnostic challenges of this case are presented.

Asunto(s)

Agranulocitosis/complicaciones; Leucemia Mieloide Aguda/complicaciones; Adolescente; Agranulocitosis/congénito; Agranulocitosis/patología; Médula Ósea/patología; Reordenamiento Génico; Humanos; Hibridación in Situ; Cariotipificación; Leucemia Mieloide Aguda/mortalidad; Leucemia Mieloide Aguda/patología; Masculino; Células Madre/fisiología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Agranulocitosis Límite: Adolescent / Humans / Male Idioma: En Revista: Am J Hematol Año: 1993 Tipo del documento: Article Pais de publicación: Estados Unidos

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