Ixr1, a yeast protein that binds to platinated DNA and confers sensitivity to cisplatin.
Science
; 261(5121): 603-5, 1993 Jul 30.
Article
en En
| MEDLINE
| ID: mdl-8342024
Structure-specific recognition proteins (SSRPs) bind to DNA containing intrastrand cross-links formed by the anticancer drug cisplatin. A yeast gene encoding an SSRP, designated IXR1, was cloned and sequenced. The Ixr1 protein, a member of the high mobility group-box protein family, bound specifically to DNA modified with cisplatin but not inactive platinum compounds. A yeast strain with an inactivated IXR1 gene was half as sensitive to cisplatin and accumulated one-third as many platinum-DNA lesions after treatment with cisplatin as the parental strain. These findings suggest that SSRPs play a role in mediating the cytotoxicity of cisplatin.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Saccharomyces cerevisiae
/
ADN
/
ADN de Hongos
/
Proteínas Fúngicas
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Proteínas del Grupo de Alta Movilidad
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Cisplatino
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Aductos de ADN
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Proteínas de Saccharomyces cerevisiae
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Proteínas de Unión al ADN
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Science
Año:
1993
Tipo del documento:
Article
Pais de publicación:
Estados Unidos