Your browser doesn't support javascript.
loading
Induction of apoptosis by the low-affinity NGF receptor.
Rabizadeh, S; Oh, J; Zhong, L T; Yang, J; Bitler, C M; Butcher, L L; Bredesen, D E.
Afiliación
  • Rabizadeh S; Department of Neurology, University of California, Los Angeles 90024.
Science ; 261(5119): 345-8, 1993 Jul 16.
Article en En | MEDLINE | ID: mdl-8332899
Nerve growth factor (NGF) binding to cellular receptors is required for the survival of some neural cells. In contrast to TrkA, the high-affinity NGF receptor that transduces NGF signals for survival and differentiation, the function of the low-affinity NGF receptor, p75NGFR, remains uncertain. Expression of p75NGFR induced neural cell death constitutively when p75NGFR was unbound; binding by NGF or monoclonal antibody, however, inhibited cell death induced by p75NGFR. Thus, expression of p75NGFR may explain the dependence of some neural cells on NGF for survival. These findings also suggest that p75NGFR has some functional similarities to other members of a superfamily of receptors that include tumor necrosis factor receptors, Fas (Apo-1), and CD40.
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Factor de Crecimiento Nervioso / Apoptosis / Factores de Crecimiento Nervioso / Neuronas Límite: Animals Idioma: En Revista: Science Año: 1993 Tipo del documento: Article Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Factor de Crecimiento Nervioso / Apoptosis / Factores de Crecimiento Nervioso / Neuronas Límite: Animals Idioma: En Revista: Science Año: 1993 Tipo del documento: Article Pais de publicación: Estados Unidos