Preventing restenosis with fish oils following coronary angioplasty. A meta-analysis.
Arch Intern Med
; 153(13): 1595-601, 1993 Jul 12.
Article
en En
| MEDLINE
| ID: mdl-8323422
BACKGROUND: No medical therapy has been shown to reduce the rate of restenosis following percutaneous transluminal coronary angioplasty. We examined the existing evidence for the use of omega-3 fatty acids in this capacity with the tool of meta-analysis. METHODS: A computerized search and a bibliographic review of published articles were performed. Abstracts were identified through journals, Index Medicus, and an unpublished listing of recent requests for fish oil for experimental use. All English-language randomized clinical trials with available reports were included in the analysis. The quality, design differences, and outcomes were evaluated for each study. RESULTS: For four studies that used angiography to define coronary restenosis, the absolute difference in restenosis rates between treatment and control groups was 13.9% (95% confidence interval [CI], 3.2% to 24.5%). Furthermore, regression analysis revealed a positive linear relationship between the dose of omega-3 fatty acids used and the absolute difference in restenosis rates (r = .99, P < .03). When three studies that used stress testing as a means of determining restenosis rates were added to the four studies that used angiography, the risk difference was 5.1% (95% CI, -3.8% to 13.9%). CONCLUSIONS: Restenosis after coronary angioplasty is reduced by supplemental fish oils, and the extent of the observed benefit may be dependent on the dose of omega-3 fatty acids used.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aceites de Pescado
/
Angioplastia Coronaria con Balón
/
Enfermedad Coronaria
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Arch Intern Med
Año:
1993
Tipo del documento:
Article
Pais de publicación:
Estados Unidos