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An additional case of pachygyria, joint contractures and facial abnormalities.
Levin, M L; Lupski, J R; Carpenter, R J; Gerson, L P; Greenberg, F.
Afiliación
  • Levin ML; Institute for Molecular Genetics, Baylor College of Medicine, Houston, TX 77030.
Clin Dysmorphol ; 2(4): 365-8, 1993 Oct.
Article en En | MEDLINE | ID: mdl-8305968
Two previous case reports have described an apparently new lethal syndrome consisting of pachygyria, joint contractures and facial abnormalities (Winter et al., 1989; Tsukahara et al., 1990). Another report describes a non-lethal case in which dysmorphic features were not noted (Massa et al., 1988). We now report on what appears to be an additional lethal case. This male infant had a lethal condition with features of large fontanelle, pachygyria with incomplete opercularization, varus contractures of the hands and feet, small palpebral fissures, hypertelorism, a small penis, cryptorchidism, camptodactyly and a sandal gap deformity. These cases appear to represent a new lethal lissencephaly syndrome associated with arthrogryposis and facial dysmorphism, which we propose to call the Winter-Tsukahara syndrome.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anomalías Múltiples / Encéfalo / Contractura / Cara / Articulaciones Límite: Adult / Female / Humans / Male / Newborn Idioma: En Revista: Clin Dysmorphol Asunto de la revista: TERATOLOGIA Año: 1993 Tipo del documento: Article Pais de publicación: Reino Unido
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anomalías Múltiples / Encéfalo / Contractura / Cara / Articulaciones Límite: Adult / Female / Humans / Male / Newborn Idioma: En Revista: Clin Dysmorphol Asunto de la revista: TERATOLOGIA Año: 1993 Tipo del documento: Article Pais de publicación: Reino Unido