[Comparison between the effects of (-)- and (+)-gossypol on protein kinase C and protein kinase A].

Xiao, D M; Zhou, W H; Zhang, Y H; Wang, X L; Zhu, B; Zhang, J B; Yang, G D; Chen, H C

Xiao, D M; Zhou, W H; Zhang, Y H; Wang, X L; Zhu, B; Zhang, J B; Yang, G D; Chen, H C.

Afiliación

Xiao DM; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing.

Yao Xue Xue Bao ; 28(7): 494-8, 1993.

Article en Zh | MEDLINE | ID: mdl-8285048

RESUMEN

Protein kinase C(PKC) and protein kinase A(PKA) purified from rat liver were incubated with (-)- and (+)-gossypol. The activity of PKC was significantly inhibited in a concentration-dependent manner by both (-)-gossypol and (+)-gossypol. (-)-gossypol was found to inhibit type I PKA, whereas the inhibitory action of (+)-gossypol for type I PKA was less potent. Both (-)-gossypol and (+)-gossypol showed inhibition for type II PKA only at high concentration. These results suggest that administration of gossypol might impair cellular signal transduction.

Asunto(s)

Proteínas Quinasas Dependientes de AMP Cíclico/metabolismo; Gosipol/farmacología; Proteína Quinasa C/metabolismo; Animales; Proteína Quinasa Tipo II Dependiente de AMP Cíclico; Proteínas Quinasas Dependientes de AMP Cíclico/aislamiento & purificación; Relación Dosis-Respuesta a Droga; Hígado/química; Masculino; Proteína Quinasa C/aislamiento & purificación; Ratas; Ratas Wistar; Estereoisomerismo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Quinasa C / Gosipol / Proteínas Quinasas Dependientes de AMP Cíclico Límite: Animals Idioma: Zh Revista: Yao Xue Xue Bao Año: 1993 Tipo del documento: Article Pais de publicación: China

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