Changes in red blood cells with valproate therapy.

Ozkara, C; Dreifuss, F E; Apperson Hansen, C

Ozkara, C; Dreifuss, F E; Apperson Hansen, C.

Afiliación

Ozkara C; Comprehensive Epilepsy Program, University of Virginia, Charlottesville 22908.

Acta Neurol Scand ; 88(3): 210-2, 1993 Sep.

Article en En | MEDLINE | ID: mdl-8256557

RESUMEN

Increase in the red blood cell mean corpuscular volume (MCV), and mean corpuscular haemoglobin (MCH) values in patients receiving Valproate as mono or polytherapy was noted. To investigate this situation 41 epileptic patients were studied on Valproate alone (Group 1) and 20 patients on Valproate added to another antiepileptic drug (AED), (Group 4), and compared with 19 patients on carbamazepine (CBZ) (Group 2) and 12 patients on phenytoin (PHT), (Group 3). The results showed significant rise in MCV values in Groups 1 and 4. The peripheral blood smear and other tests including reticulocyte counts of the patients with abnormal values ruled out macrocytic anemias. We postulate a generalized effect which is the result of alteration in erythrocyte membrane phospholipids.

Asunto(s)

Epilepsia/sangre; Eritrocitos/efectos de los fármacos; Ácido Valproico/farmacología; Anemia Macrocítica/inducido químicamente; Plaquetas/efectos de los fármacos; Epilepsia/tratamiento farmacológico; Índices de Eritrocitos; Volumen de Eritrocitos/efectos de los fármacos; Femenino; Humanos; Masculino; Trombocitopenia/inducido químicamente; Ácido Valproico/efectos adversos; Ácido Valproico/uso terapéutico

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Valproico / Epilepsia / Eritrocitos Límite: Female / Humans / Male Idioma: En Revista: Acta Neurol Scand Año: 1993 Tipo del documento: Article Pais de publicación: Dinamarca

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