Atrial natriuretic peptide attracts human spermatozoa in vitro.

Zamir, N; Riven-Kreitman, R; Manor, M; Makler, A; Blumberg, S; Ralt, D; Eisenbach, M

Zamir, N; Riven-Kreitman, R; Manor, M; Makler, A; Blumberg, S; Ralt, D; Eisenbach, M.

Afiliación

Zamir N; Department of Physiology, Sackler Faculty of Medicine, Tel Aviv University, Israel.

Biochem Biophys Res Commun ; 197(1): 116-22, 1993 Nov 30.

Article en En | MEDLINE | ID: mdl-8250915

RESUMEN

Here we report that atrial natriuretic peptide (ANP), a known activator of particulate guanylate cyclase, induces attraction and swimming speed enhancement of human spermatozoa in vitro. Using capillary assays under a variety of experimental conditions (ascending or descending gradients of ANP, or no gradient at all) and microscopic assays in which individual spermatozoa could be followed, we found that spermatozoa followed the gradient of ANP and accumulated in it. Speed enhancement was detected in the presence of ANP without a gradient. These observations suggest either that an ANP-like substance is the physiological attractant for human spermatozoa, or, more likely, that ANP directly affects guanylate cyclase in a manner similar to that caused by the physiological attractant.

Asunto(s)

Factor Natriurético Atrial/farmacología; Quimiotaxis/efectos de los fármacos; Espermatozoides/efectos de los fármacos; Glicopéptidos/farmacología; Humanos; Masculino; Neprilisina/antagonistas & inhibidores

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espermatozoides / Quimiotaxis / Factor Natriurético Atrial Límite: Humans / Male Idioma: En Revista: Biochem Biophys Res Commun Año: 1993 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos

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