The IgG2a antibody response to thyroglobulin is linked to the Igh locus in mouse.

Kuppers, R C; Epstein, L D; Outschoorn, I M; Rose, N R

Kuppers, R C; Epstein, L D; Outschoorn, I M; Rose, N R.

Afiliación

Kuppers RC; Department of Immunology and Infectious Disease, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205.

Immunogenetics ; 39(6): 404-11, 1994.

Article en En | MEDLINE | ID: mdl-8188317

RESUMEN

The IgG-subclass usage by several strains of mice in the response to immunization with mouse thyroglobulin (mTg) was examined in the experimental autoimmune thyroiditis model. While the subclass usage by most mouse strains was similar, the Ighb allotype-bearing mice consistently produced lower IgG2a levels to mTg. Using CBA-Ighb congenic and recombinant inbred strains of mice, the lower level of IgG2a in the Ighb mouse was mapped to the Igh locus. The regulation of IgG2a appeared to be cis controlled, as the CBA x C57BL/6F1 mouse also produced reduced IgG2a of the Ighb (B6) allotype but not of the Ighj (CBA) allotype.

Asunto(s)

Ligamiento Genético; Inmunoglobulina G/genética; Cadenas Pesadas de Inmunoglobulina/genética; Tiroglobulina/inmunología; Tiroiditis Autoinmune/genética; Animales; Mapeo Cromosómico; Cruzamientos Genéticos; Regulación de la Expresión Génica; Haplotipos/genética; Ratones; Ratones Endogámicos CBA; Tiroiditis Autoinmune/inmunología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiroglobulina / Tiroiditis Autoinmune / Inmunoglobulina G / Cadenas Pesadas de Inmunoglobulina / Ligamiento Genético Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Immunogenetics Año: 1994 Tipo del documento: Article Pais de publicación: Estados Unidos

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