Stability of carboplatin in 5% glucose solution in glass, polyethylene and polypropylene containers.
J Pharm Biomed Anal
; 12(1): 81-4, 1994 Jan.
Article
en En
| MEDLINE
| ID: mdl-8161609
The degradation of carboplatin (3.2 mg ml-1) in 5% glucose infusion solution at 25 degrees C and protected from light was investigated. The effects of the material of the container and temperature were also studied. Solutions were prepared in 5% glucose solution and stored in glass bottles, polyethylene (PE) and polypropylene (PP) containers at 40, 50 and 60 degrees C and at 25 degrees C +/- 1 degrees C. Samples were assayed by an HPLC method to determine the residual carboplatin concentration at each time of sampling. Carboplatin degradation followed pseudo-first-order kinetics and no dependence on the nature of the container was found. After 1 month at 25 degrees (+/- 1 degrees)C the change in carboplatin concentration was < 2% of the initial concentration in 5% glucose. These results are in agreement with those predicted by the application of the Arrhenius equation.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carboplatino
/
Embalaje de Medicamentos
Idioma:
En
Revista:
J Pharm Biomed Anal
Año:
1994
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Reino Unido