Sulfasalazine-associated encephalopathy in a patient with Crohn's disease.
Am J Gastroenterol
; 88(10): 1759-63, 1993 Oct.
Article
en En
| MEDLINE
| ID: mdl-8105680
We report a case of acute encephalopathy in a patient with Crohn's disease who had taken sulfasalazine for 1 month. The development of toxic hepatitis and dermatitis prompted interruption of the drug. Four days later, neurologic symptoms became evident. These included acute monoparesis of the left arm, the development of stupor and coma, with endorotation of both arms, and a left Babinski sign. CT and MR imaging revealed multiple lesions in the white and gray brain matter, suggesting diffuse cerebral microangiitis. All cerebrospinal fluid examinations were negative. Methylprednisolone was given intravenously. Complete clinical normalization followed. Neurotoxicity secondary to sulfasalazine has seldom been reported in the literature. We found certain similarities with two previous case reports suggesting a hypersensitivity reaction to sulfasalazine or one of its metabolites. For ethical reasons, no rechallenge was performed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sulfasalazina
/
Encefalopatías
/
Enfermedad de Crohn
/
Hipersensibilidad a las Drogas
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Aspecto:
Ethics
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Gastroenterol
Año:
1993
Tipo del documento:
Article
País de afiliación:
Bélgica
Pais de publicación:
Estados Unidos