Technetium-99m labeled somatostatin and analogs: synthesis, characterization and in vivo evaluation.
Nucl Med Biol
; 20(4): 539-43, 1993 May.
Article
en En
| MEDLINE
| ID: mdl-8099301
Technetium-99m complexes of somatostatin and analogs were synthesized following the introduction of sulfhydryl groups with 2-iminothiolane (Traut's Reagent). In rats the complex was taken up by the liver, kidneys, adrenals, lungs and the pancreas. Analysis of urine samples of treated rats showed that the radiochemicals have reasonably good in vivo stability. This implies that the complexes may be potentially useful for biochemical characterization of somatostatin receptors and also in scintigraphic detection of somatostatin receptor positive tumors, especially for metastatic deposits in patients on somatostatin therapy.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Somatostatina
/
Compuestos de Organotecnecio
Límite:
Animals
Idioma:
En
Revista:
Nucl Med Biol
Asunto de la revista:
BIOLOGIA
/
MEDICINA NUCLEAR
Año:
1993
Tipo del documento:
Article
Pais de publicación:
Estados Unidos