Proteinergic profiles in cerebrospinal fluid from alcoholic subjects.
Biomed Chromatogr
; 8(3): 137-41, 1994.
Article
en En
| MEDLINE
| ID: mdl-8075523
Minute amounts of cerebrospinal fluid samples from alcoholics were subjected to separation by HPLC-molecular sieving, combined with multispectral UV analysis of the acquired data. A significant difference in the protein/polypeptide pattern within the molecular weight range of 7-10 kDa has been observed between samples, taken directly after detoxification and 2 weeks later. Spectral analysis of the results suggests that the components are of peptidergic nature. On the other hand, albumin content did not differ significantly, suggesting that the blood-brain barrier was not affected. An enzyme marker, dynorphin converting enzyme, remained unchanged in both groups.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas del Líquido Cefalorraquídeo
/
Cromatografía Líquida de Alta Presión
/
Alcoholismo
Límite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biomed Chromatogr
Año:
1994
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Reino Unido