Insulin-like growth factor II intron sequences support the hominoid rate-slowdown hypothesis.
Mol Phylogenet Evol
; 2(4): 315-21, 1993 Dec.
Article
en En
| MEDLINE
| ID: mdl-8049780
Nucleotide sequences were obtained from the approximately 1.7 kb intron 7 of the insulin-like growth factor II gene in human and representatives of both Old World and New World monkeys and analyzed with additional published noncoding regions (both introns and flanking regions) that differ substantially in base composition (GC content). Relative rate tests, utilized to examine differential rates of molecular evolution between humans and Old World monkeys, support the hypothesis that the rate of nucleotide substitution is slower in humans than in Old World monkeys. Comparisons of approximately 4,300 nucleotide positions revealed a significantly higher evolutionary rate in the Old World monkey lineage than in the human lineage for both intron sequences and flanking regions. The data indicate that the molecular clock hypothesis is not applicable to the human and Old World monkey lineages and that the hominoid rate slowdown is a general phenomenon--it is not unique to a particular gene region and is not influenced by regional differences in base composition.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor II del Crecimiento Similar a la Insulina
/
Intrones
/
Hominidae
/
Evolución Biológica
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Phylogenet Evol
Asunto de la revista:
BIOLOGIA
/
BIOLOGIA MOLECULAR
Año:
1993
Tipo del documento:
Article
Pais de publicación:
Estados Unidos