Alcohol-induced changes in the immune response: immunological effects of chronic ethanol intake are genetically regulated.
Toxicol Appl Pharmacol
; 127(1): 37-43, 1994 Jul.
Article
en En
| MEDLINE
| ID: mdl-8048051
Experimental evidence on the immunomodulating effects of ethanol is contradictory and, in animals, the immunological effects of long-term alcohol intake may depend on the age of animal, amount of alcohol consumed, and nutritional composition of the administered diet. In this study, immunological effects of pair-feeding a 35% ethanol-containing Bio-Serv liquid diet for 6 weeks were evaluated using two major histocompatibility complex (MHC)-compatible inbred strains of rats (F344 and LEW). Food intake, rate of gain in body weight, and percentages of B cells, T cells, and T cell subtypes were not affected by ethanol intake. Also, proliferative responses of lymphocytes to T and B cell mitogens were similar in control and ethanol-fed groups of the two strains. Ethanol consumption had no significant influence on spleen weights and the antibody plaque-forming cell (PFC) response in F344 rats; however, in LEW rats, ethanol ingestion leads to a significant decrease (about 16%; p < 0.012) in spleen weight and a > 75% reduction in the PFC response. These results suggest that a non-MHC-encoded gene(s) regulates the ethanol-mediated immunosuppression of the PFC response. Thus, LEW-F344 combination may provide an excellent model to characterize genetic factors which determine sensitivity/resistance to immunological effects of ethanol ingestion.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bazo
/
Etanol
/
Genes
/
Tolerancia Inmunológica
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Toxicol Appl Pharmacol
Año:
1994
Tipo del documento:
Article
Pais de publicación:
Estados Unidos