Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function.
J Exp Med
; 180(2): 705-9, 1994 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-8046345
Regulation of macrophage scavenger receptor (MSR) activity may be an important determinant of the extent of atherogenesis. The effect of macrophage-colony-stimulating factor (M-CSF) on this pathway was studied using a recently developed monoclonal antibody to murine MSR. M-CSF markedly and selectively increased MSR synthesis in murine macrophages: posttranslationally, the receptor appeared more stable and shifted to a predominantly surface distribution. Functionally, M-CSF enhanced modified lipoprotein uptake and increased divalent cation-independent adhesion in vitro. These results suggest a plausible mechanism whereby M-CSF production in the atheromatous plaque microenvironment could promote the recruitment and retention of mononuclear phagocytes and subsequent foam cell formation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores Inmunológicos
/
Factor Estimulante de Colonias de Macrófagos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Exp Med
Año:
1994
Tipo del documento:
Article
Pais de publicación:
Estados Unidos