Solution structure of human interleukin-1 receptor antagonist protein.

Stockman, B J; Scahill, T A; Strakalaitis, N A; Brunner, D P; Yem, A W; Deibel, M R

Stockman, B J; Scahill, T A; Strakalaitis, N A; Brunner, D P; Yem, A W; Deibel, M R.

Afiliación

Stockman BJ; Upjohn Laboratories, Upjohn Company, Kalamazoo, MI 49007.

FEBS Lett ; 349(1): 79-83, 1994 Jul 25.

Article en En | MEDLINE | ID: mdl-8045306

RESUMEN

Interleukin-1 receptor antagonist protein (IRAP) is a naturally occurring inhibitor of the interleukin-1 receptor. In contrast to IL-1 beta, IRAP binds to the IL-1 receptor but does not elicit a physiological response. We have determined the solution structure of IRAP using NMR spectroscopy. While the overall topology of the two 153-residue proteins is quite similar, functionally critical differences exist concerning the residues of the linear amino acid sequence that constitute structurally homologous regions in the two proteins. Structurally homologous residues important for IL-1 receptor binding are conserved between IRAP and IL-1 beta. By contrast, structurally homologous residues critical for receptor activation are not conserved between the two proteins.

Asunto(s)

Receptores de Interleucina-1/antagonistas & inhibidores; Sialoglicoproteínas/química; Secuencia de Aminoácidos; Proteína Antagonista del Receptor de Interleucina 1; Interleucina-1/química; Interleucina-1/metabolismo; Espectroscopía de Resonancia Magnética; Modelos Moleculares; Datos de Secuencia Molecular; Conformación Proteica; Receptores de Interleucina-1/metabolismo; Proteínas Recombinantes/química; Soluciones

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sialoglicoproteínas / Receptores de Interleucina-1 Tipo de estudio: Prognostic_studies Idioma: En Revista: FEBS Lett Año: 1994 Tipo del documento: Article Pais de publicación: Reino Unido

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