Use of an allogeneic antigen to induce resistance and regression of an autologous tumor.
J Immunother Emphasis Tumor Immunol
; 15(3): 202-11, 1994 Apr.
Article
en En
| MEDLINE
| ID: mdl-8032543
Studies were initiated to determine if it was possible to use a tumor-bearing animal's own spleen cells to impart resistance to its neoplasm. YC8 T-cell lymphoma-bearing BALB/c mice (TBAs) were immunized with allogeneic DBA/2 spleen cells, which share cross-reacting antigens with the YC8 tumor. Animals immunized with the alloantigen were splenectomized and their spleen cells co-cultured with additional alloantigens for 2 days in media containing 2% polyethylene glycol (PEG) before being returned to the cyclophosphamide (cytoxan) (Ctx) pretreated autologous host. Treatment with Ctx was used to reduce suppressor factors in the TBA. It was found that when cultured spleen cells were returned to the autologous TBA, much greater resistance was imparted to the host and, in many instances, regression of the YC8 tumor was observed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunoterapia Adoptiva
/
Linfoma de Células T
/
Isoantígenos
Límite:
Animals
Idioma:
En
Revista:
J Immunother Emphasis Tumor Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
/
NEOPLASIAS
Año:
1994
Tipo del documento:
Article
Pais de publicación:
Estados Unidos