Expression of insulin-like growth factor II (IGF-II) in human hepatocellular carcinomas: an immunohistochemical study.
Pathol Int
; 44(2): 131-7, 1994 Feb.
Article
en En
| MEDLINE
| ID: mdl-8025652
Recent results obtained using molecular biology techniques have suggested a possible role for insulin-like growth factor II (IGF-II) in the pathogenesis of hepatocellular carcinoma (HCC). To investigate this phenomenon, a monoclonal antibody was used against IGF-II to study 54 patients with HCC. The presence of HBsAg was also tested both in serum and liver tissue. A positive immunoreaction was found in 9/15 (60%) of the HCC arising in cirrhotic livers of patients who had serum markers for HBV (HBV + positive patients). These results provide further evidence that HBV might play a role in the expression of IGF-II. In HCC of patients without any markers of HBV infection (HBV- negative patients), IGF-II was detected in 10/39 (25.6%) of the tumors, and in some benign neoplastic lesions. It was found not only in neoplastic cells but also in some dysplastic nodules. The speculation arises that IGF-II expression may play a role in some steps of hepato-carcinogenesis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor II del Crecimiento Similar a la Insulina
/
Carcinoma Hepatocelular
/
Hepatopatías
/
Neoplasias Hepáticas
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Pathol Int
Asunto de la revista:
PATOLOGIA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Australia