The neu-oncogene: more than a prognostic indicator?
Hum Pathol
; 25(12): 1264-8, 1994 Dec.
Article
en En
| MEDLINE
| ID: mdl-8001919
Overexpression of the neu-protein, evidenced as membrane staining by immunohistochemistry, is detected in approximately 20% of invasive duct cell carcinomas, in approximately 50% of in situ duct cell carcinomas, and in almost 100% of cases of Paget's disease. Apart from a growth stimulatory effect, the molecule plays an important role in cell motility of tumor cells by the activity of a motility factor, which acts as a specific ligand for the neu-protein. The motility factor induces chemotaxis of neu-overexpressing breast cancer cells. The motility function of the neu-protein may lead to an increased metastatic potential of neu-overexpressing breast tumors. Also in Paget's disease of the breast, a motility factor secreted by epidermal keratinocytes attracts the neu-overexpressing Paget's cells by chemotaxis and leads to invasion of the epidermis by the tumor cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptor ErbB-2
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Hum Pathol
Asunto de la revista:
PATOLOGIA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Bélgica
Pais de publicación:
Estados Unidos