Effects of microgravity and increased gravity on bone marrow of rats.
Aviat Space Environ Med
; 65(8): 730-5, 1994 Aug.
Article
en En
| MEDLINE
| ID: mdl-7980333
Astronauts have a reduction in their red cell mass when exposed to microgravity. This is probably mainly due to a physiological response to decreased energy requirements. Further studies of erythropoiesis were carried out in microgravity on rats flown on Soviet Biosatellite 2044 and in hypergravity by centrifugation at 2G. Studies included: bone marrow cell differential counts, clonal studies of RBC colony formation, and plasma erythropoietin determinations. In the bone marrow of Cosmos flight animals there was a slight increase in granulocytic cells and in centrifuged animals, a slight decrease in the percentage of erythroid cells which led to an increased M:E ratio. The bone marrow cells of flight and centrifuged rats responded to erythropoietin. Cosmos flight animals' cells formed fewer CFU-E than the controls but this was reversed in the centrifuge studies. There were no essential differences in the erythropoietin levels of test groups as compared to control groups.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vuelo Espacial
/
Ingravidez
/
Células de la Médula Ósea
/
Hipergravedad
Límite:
Animals
Idioma:
En
Revista:
Aviat Space Environ Med
Año:
1994
Tipo del documento:
Article
Pais de publicación:
Estados Unidos