History and perspectives of antiprogestins from the chemist's point of view.
Hum Reprod
; 9 Suppl 1: 12-31, 1994 Jun.
Article
en En
| MEDLINE
| ID: mdl-7962457
ABSTRACT
PIP: The discovery of RU-486 and its potent activity as an antiglucocorticoid and antiprogestin have brought the protracted story on steroid hormones and antihormones to a logical conclusion. For each of the five traditional classes of steroid hormones, estrogens, androgens, progestins, glucocorticoids, and mineralcorticoids, potent agonists and antagonists are available. The armamentarium of the steroid endocrinologist is therefore complete although scattered improvements do remain possible. RU-486 has already become the prototype of a number of analogs claimed to be either more active or more dissociated. The authors searched the literature for available data on abortive activities, including some as yet unpublished results on RU compounds. It appears that a number of compounds are both more active than RU-486 on a dose basis in animal studies and more dissociated in relation to a possible antiglucocorticoid activity. Moreover, hydrosoluble compounds suitable for IV injection are available for possible development. Over the long-term, it is possible that nonsteroidal antiprogestins may present additional advantages over steroidal compounds, in particular improved receptor specificity and/or reduced susceptibility to receptor mutation.
Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Progestinas
/
Antagonistas de Hormonas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Hum Reprod
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido