Differences in the reserpine-sensitive storage in vivo of 1-methyl-4-phenylpyridinium in rats and mice may explain differences in catecholamine toxicity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Russo, S M; Daniels, A J; Viveros, O H; Reinhard, J F

Russo, S M; Daniels, A J; Viveros, O H; Reinhard, J F.

Afiliación

Russo SM; Cellular & Molecular Pharmacology Section, Division of Pharmacology, Wellcome Research Laboratories, Research Triangle Park, NC 27709.

Neurotoxicol Teratol ; 16(3): 277-81, 1994.

Article en En | MEDLINE | ID: mdl-7935261

RESUMEN

Administration of reserpine, an inhibitor of vesicular catecholamine storage, differentially reduced the accumulation of MPP+ formed from MPTP in rats and mice. The effects were most pronounced in the adrenal gland for either species. In rats, reserpine decreased striatal and hippocampal MPP+ levels while in mice reserpine did not affect the disposition of MPP+ in the striatum but decreased hippocampal MPP+. The data suggest that mice may be more sensitive to the toxicant because less striatal MPP+ appears to be stored in the reserpine-sensitive storage vesicle.

Asunto(s)

1-Metil-4-fenilpiridinio/metabolismo; Intoxicación por MPTP; Receptores de Catecolaminas/efectos de los fármacos; Reserpina/farmacología; Animales; Masculino; Ratones; Ratones Endogámicos C57BL; Ratas; Especificidad de la Especie

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reserpina / 1-Metil-4-fenilpiridinio / Receptores de Catecolaminas / Intoxicación por MPTP Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: Neurotoxicol Teratol Asunto de la revista: NEUROLOGIA / TOXICOLOGIA Año: 1994 Tipo del documento: Article Pais de publicación: Estados Unidos

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