Heat shock proteins hsp90 and hsp70 protect neuronal cells from thermal stress but not from programmed cell death.

Mailhos, C; Howard, M K; Latchman, D S

Mailhos, C; Howard, M K; Latchman, D S.

Afiliación

Mailhos C; Department of Molecular Pathology, University College London Medical School, England.

J Neurochem ; 63(5): 1787-95, 1994 Nov.

Article en En | MEDLINE | ID: mdl-7931334

RESUMEN

Prior exposure to a mild thermal stress can protect neuronal cells from a subsequent more severe stress including high temperature, ischemia, glutamate toxicity, or stimuli inducing apoptosis. Although the protective effect of thermal stress correlates with the elevated expression of the heat shock proteins (hsps), the protective effect of individual hsps has never been directly demonstrated in neuronal cells. Here we show that the constitutive overexpression of either of the major hsps, hsp90 or hsp70, can protect neuronal cells from thermal stress but not from stimuli that induce apoptosis. The possible mechanisms by which thermal stress can protect neuronal cells from apoptosis are discussed.

Asunto(s)

Apoptosis; Proteínas HSP70 de Choque Térmico/farmacología; Proteínas HSP90 de Choque Térmico/farmacología; Calor; Neuronas/citología; Neuronas/fisiología; Animales; Apoptosis/efectos de los fármacos; Western Blotting; Células Cultivadas; Ganglios Espinales/citología; Ganglios Espinales/efectos de los fármacos; Ganglios Espinales/fisiología; Neuroblastoma/patología; Neuronas/efectos de los fármacos; Ratas; Ratas Sprague-Dawley; Transfección; Células Tumorales Cultivadas

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoptosis / Proteínas HSP90 de Choque Térmico / Proteínas HSP70 de Choque Térmico / Calor / Neuronas Límite: Animals Idioma: En Revista: J Neurochem Año: 1994 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido

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