Prostaglandins, thromboxanes, leukotrienes, and cytochrome P-450 metabolites of arachidonic acid.
New Horiz
; 1(1): 60-9, 1993 Feb.
Article
en En
| MEDLINE
| ID: mdl-7922394
Arachidonic acid is metabolized via three major enzymatic pathways: cyclooxygenase, lipoxygenase, and cytochrome P-450. The cyclooxygenase pathway gives rise to the prostaglandins and thromboxane A2. The lipoxygenase pathway produces the leukotrienes and 5-, 12-, and 15-hydroxyeicosatetraenoic acids. The cytochrome P-450 pathway metabolites are oxygenated metabolites of arachidonic acid. Synthesis of several of the cyclooxygenase and lipoxygenase metabolites are increased in circulatory shock. A potential role for several of these compounds in the pathophysiologic sequelae of endotoxic and septic shock has been implied from a combination of animal and human studies. There are no studies that have explored a potential role for cytochrome P-450 metabolites in the pathogenesis of circulatory shock.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Prostaglandinas
/
Tromboxanos
/
Leucotrienos
/
Ácido Araquidónico
/
Sistema Enzimático del Citocromo P-450
Límite:
Animals
/
Humans
Idioma:
En
Revista:
New Horiz
Asunto de la revista:
TERAPIA INTENSIVA
Año:
1993
Tipo del documento:
Article
Pais de publicación:
Estados Unidos