The influence of GABA-ergic system on clonidine analgesia in rats.
Pol J Pharmacol
; 46(5): 409-15, 1994.
Article
en En
| MEDLINE
| ID: mdl-7894527
The effect of agonists and antagonists of GABA-ergic system on analgesia induced by clonidine was investigated in the rat. The compounds activating (muscimol, 1 mg/kg and aminooxyacetic acid; AOAA, 25 mg/kg) or inhibiting GABA-ergic receptors (bicuculline and picrotoxin, in subconvulsive doses 0.5-1 mg/kg) do not change clonidine-induced analgesia. Only the higher dose (2 mg/kg) of muscimol, bicuculline or picrotoxin affected clonidine-induced analgesia. Baclofen, contrary to other GABA agonists, markedly potentiated clonidine-induced analgesia in the dose dependent manner. These results suggest that compounds activating and inhibiting GABA A receptors (muscimol, AOAA, bicuculline and picrotoxin) have a weak influence on clonidine induced analgesia as compared to the effect of baclofen (agonist of GABA B receptors).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Clonidina
/
Receptores de GABA
/
Antagonistas del GABA
/
Agonistas del GABA
/
Analgesia
Límite:
Animals
Idioma:
En
Revista:
Pol J Pharmacol
Asunto de la revista:
FARMACOLOGIA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Polonia
Pais de publicación:
Polonia