[Cytogenetics and molecular studies confirm the histopathologic diagnosis of chronic myeloproliferative diseases]. / Zytogenetik und molekulare Untersuchungen sichern die histopathologischen Diagnosen von chronischen myeloproliferativen Erkrankungen ab.
Pathologe
; 16(1): 41-5, 1995 Jan.
Article
en De
| MEDLINE
| ID: mdl-7886013
The histopathological classification of chronic myeloproliferative disorders can be supported by applying cytogenetics and molecular genetics to the analysis of bone marrow or blood cells, as demonstrated in 253 cases evaluated. The Philadelphia translocation (9;22) is the most important genetic parameter, being specific for chronic myeloid leukemia. Conventional methods for the detection of the t(9;22) are karyotyping and Southern blot analysis of the bcr gene. The newly established technique of fluorescence in situ hybridization (FISH) allows visualization of bcr-abl fusion even in non dividing cells. Molecular cytogenetics for t(9;22) yield results that are rapid and reliable as well as easily quantifiable.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Tirosina Quinasas
/
Aberraciones Cromosómicas
/
Trastornos Mieloproliferativos
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
De
Revista:
Pathologe
Año:
1995
Tipo del documento:
Article
Pais de publicación:
Alemania