Modulation of nicotine-induced analgesia by calcium agonist and antagonist in adult rats.
Psychopharmacology (Berl)
; 110(4): 497-9, 1993.
Article
en En
| MEDLINE
| ID: mdl-7870921
The involvement of calcium in nicotine-induced analgesia in male rats was explored using the tail-flick test. A single dose of nicotine (1 mg/kg SC) produced a maximal effect on tail-flick latency (15 s) within 8-10 min, which lasted for 4 min. Pretreatment with the calcium chelator, EDTA (250 microM/kg SC four injections at 15 min intervals), before the single dose of nicotine accelerated the onset and prolonged the duration of the nicotine-induced analgesia. The maximal effect on tail-flick latency occurred within 2 min and lasted for 10-20 min. Conversely, pretreatment with calcium chloride (1.5 mM/kg IP) attenuated nicotine-induced analgesia. It is suggested that nicotine may exert its antinociceptive effects via modulation of calcium fluxes across the neural membrane.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Agonistas de los Canales de Calcio
/
Bloqueadores de los Canales de Calcio
/
Analgesia
/
Nicotina
Límite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
1993
Tipo del documento:
Article
Pais de publicación:
Alemania