Effects of a luteinizing hormone-releasing hormone analog on mating and fertility in rats.
Fertil Steril
; 27(9): 1078-84, 1976 Sep.
Article
en En
| MEDLINE
| ID: mdl-786746
ABSTRACT
PIP: The rhythmic antifertility effect of an LH-RH analog, AY-25,205, was investigated in 4-day cyclic rats. All groups (10 animals in each) received 20-120 ng/rat im between 3:00 and 3:30 P.M. the day of diestrus. Treatment continued for either 2 or 4 consecutive cycles, and subsequent injections were given either on the 3rd or 4th consecutive day; cohabitation was either unrestricted or prevented for 24 hours posttreatment. Only 1 rat of 40 in the 3-day. restricted cohabitation groups became pregnant during the 1st cycle, and the antifertility effect continued. However, for those groups treated every 4th day and allowed unrestricted cohabitation, 25 of 30 animals became pregnant the night of the 2nd injection. It is suggested that the antifertility effect of AY-25,205 is due to an ability to induce ovulation 1 day before the appearance of gonadotropin-induced lordosis. AY-25,205 or similar analogs may have application in humans by making more precise the time of ovulation, which would permit more effective use of the "rhythm method" of birth control.
Palabras clave
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta Sexual Animal
/
Hormona Liberadora de Gonadotropina
/
Fertilidad
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Fertil Steril
Año:
1976
Tipo del documento:
Article
Pais de publicación:
Estados Unidos