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Do enzyme inducers modify haloperidol decanoate rate of release?
Pupeschi, G; Agenet, C; Levron, J C; Barges-Bertocchio, M H.
Afiliación
  • Pupeschi G; Montperrin Hospital, Aix-en-Provence, France.
Article en En | MEDLINE | ID: mdl-7863019
1. Plasma levels were monitored for about 18 months during therapy with haloperidol decanoate. When steady-state was reached, patients treated without enzyme inducers showed in their plasma concentrations a stable plateau and a very low fluctuation. Furthermore, doses were correlated to plasma levels (r = 0.9). 2. Contrary, patients treated with both haloperidol decanoate and enzyme inducers seemed to present in their plasma concentration a very large fluctuation with C min (plasma concentrations measured just before the injection) significantly lower than those of the other group. Moreover their C min values were excluded from the linear regression curve calculated between plasma levels and doses in patients without enzyme inducers. 3. Our data suggest a shortening of the absorption half-time of haloperidol. In this case, it seems necessary to diminish the interval between injections than to give higher dosage in order to maintain plasma concentrations.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenobarbital / Esquizofrenia / Antipsicóticos / Carbamazepina / Haloperidol Límite: Humans Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 1994 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenobarbital / Esquizofrenia / Antipsicóticos / Carbamazepina / Haloperidol Límite: Humans Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 1994 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido