GABA-transaminase in brain and blood platelets: basic and clinical aspects.
Prog Neuropsychopharmacol Biol Psychiatry
; 18(8): 1219-33, 1994 Dec.
Article
en En
| MEDLINE
| ID: mdl-7863013
Several lines of evidence suggest that the major inhibitory neuro-transmitter, gamma-aminobutyric acid (GABA) is involved, both directly and indirectly, in the pathogenesis of certain neurological and psychiatric disorders. The main enzyme responsible for GABA catabolism is gamma-aminobutyrate aminotransferase (GABA-T). Inhibition of this enzyme produces a considerable elevation of brain GABA concentrations, and such elevation has been correlated with many pharmacological effects. There seems to be that, as is discussed below, GABA-T activity in the brain and/or blood platelets is related to some neuro-psychiatric disorders such as alcoholism, epilepsy and Alzheimer's disease. GABA-T has been identified in the blood platelets with similar characteristics to those of brain GABA-T. In this way, studies on GABA-T activity in neuro-psychiatric disorders could be performed to understand, diagnosis and treat GABA-related disorders of the central nervous system (CNS).
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Encéfalo
/
4-Aminobutirato Transaminasa
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Prog Neuropsychopharmacol Biol Psychiatry
Año:
1994
Tipo del documento:
Article
País de afiliación:
Libia
Pais de publicación:
Reino Unido