Erythrocyte and polymorphonuclear cell transit time and concentration in human pulmonary capillaries.
J Appl Physiol (1985)
; 77(4): 1795-800, 1994 Oct.
Article
en En
| MEDLINE
| ID: mdl-7836202
Pulmonary capillary transit times were examined in patients who required lung resection by use of 99mTc-labeled macroaggregates (99Tc-MAA) and chromium-labeled erythrocytes (51Cr-RBC) to measure regional blood flow and volume in the resected lung. Cell flow (cells.ml-1.s-1) to each resected lung sample was determined by multiplying the number of polymorphonuclear leukocytes (PMN) per milliliter of circulating blood by the blood flow to that sample. Capillary blood volume was obtained by multiplying the morphometrically determined fraction of pulmonary blood in capillaries by the total 51Cr-RBC volume in each sample. Cell concentrations (cells/ml) in capillary blood were calculated morphometrically, and capillary transit times were obtained by dividing cell concentration by cell flow. The results show that PMN transit times were 60-100 times longer than the RBC transit times, with a 22% overlap between their distributions. We conclude that PMN are concentrated with respect to RBC in pulmonary capillary blood because of differences in their transit times and that these long transit times provide an opportunity for PMN-endothelial interactions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Capilares
/
Eritrocitos
/
Pulmón
/
Neutrófilos
Límite:
Humans
/
Middle aged
Idioma:
En
Revista:
J Appl Physiol (1985)
Asunto de la revista:
FISIOLOGIA
Año:
1994
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
Estados Unidos