Effect of propylthiouracil-induced hypothyroidism on cerebral cortex of young and aged rats: lipid composition of synaptosomes, muscarinic receptor sites, and acetylcholinesterase activity.
Neurochem Res
; 19(9): 1181-6, 1994 Sep.
Article
en En
| MEDLINE
| ID: mdl-7824072
The effect of hypothyroidism on the lipid composition of synaptosomes, density and affinity of muscarinic receptor sites, and acetylcholinesterase activity in the cerebral cortex of young and aged rats was investigated. The animals were made hypothyroid by adding 0.05% propyl-2-thiouracil to their drinking water for four weeks. This pathological state induced an increase in the relative percentage of sphingomyelin in young rats. In aged rats hypothyroidism induced a decrease of sphingomyelin and glycerophosphocholine and an increase of cholesterol. The effect of hypothyroid state on cerebral cortex resulted in an increase of acethylcholinesterase activity both in young and aged rats and was also reflected in an increase of density of M1-AChRs but only in the former.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Acetilcolinesterasa
/
Sinaptosomas
/
Corteza Cerebral
/
Receptores Muscarínicos
/
Metabolismo de los Lípidos
/
Hipotiroidismo
Límite:
Animals
Idioma:
En
Revista:
Neurochem Res
Año:
1994
Tipo del documento:
Article
País de afiliación:
Italia
Pais de publicación:
Estados Unidos