[Synthesis of tert-butylcyclopentane-fused 1,3-oxazines and 1,3-thiazines]. / terc-Butil-ciklopentánnal kondenzált 1,3-oxazinok és 1,3-tiazinok szintézise.
Acta Pharm Hung
; 64(5): 153-7, 1994 Sep.
Article
en Hu
| MEDLINE
| ID: mdl-7817766
Chlorosulphonyl isocyanate (CSI) addition to 4-tert-butylcyclopentene furnished the azetidinone (3) in a stereospecific reaction. Azetidinone 3 was transformed by ring opening esterification and lithium aluminium hydride (LAH) reduction to the 2-hydroxy-methyl-4-tert-butyl-1-cyclopentylamine (6). The N-methyl-aminoalcohol (8) was prepared from amino esters (5) with ethyl chloroformate and subsequent LAH reduction. By different ring-closure methods, a number of tert-butyl-cyclopentante-fused 1,3-oxazines and 1,3-thiazines were synthesized. A comparative study of the prepared compounds was performed by IR, 1H- and 13C-NMR, DEPT and DNOE measurements.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxazinas
/
Tiazinas
Idioma:
Hu
Revista:
Acta Pharm Hung
Año:
1994
Tipo del documento:
Article
Pais de publicación:
Hungria