Reproductive toxicology of alkylating agents.

Glantz, J C

Glantz, J C.

Afiliación

Glantz JC; University of Rochester School of Medicine and Dentistry, Department of Obstetrics and Gynecology, New York.

Obstet Gynecol Surv ; 49(10): 709-15, 1994 Oct.

Article en En | MEDLINE | ID: mdl-7816395

RESUMEN

Alkylating agents have been used during childhood and in reproductive age groups for the treatment of malignancy or collagen-vascular disease. Because of their mechanism of action, alkylating agents have the ability to interfere with chromosomal structure, ovarian function, spermatogenesis, and embryogenesis. Teratogenic risks have been established in animal studies, although are less clear for humans. Total dose, timing of administration, and age of the patient at the time of therapy are all factors in determining adverse effects. If possible, alkylating agents should be avoided in the first trimester, but can be used during the remainder of pregnancy.

Asunto(s)

Alquilantes/efectos adversos; Reproducción/efectos de los fármacos; Factores de Edad; Alquilantes/clasificación; Cromosomas/efectos de los fármacos; Modelos Animales de Enfermedad; Femenino; Feto/efectos de los fármacos; Genitales/efectos de los fármacos; Humanos; Embarazo; Primer Trimestre del Embarazo; Teratógenos

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Reproducción / Alquilantes Tipo de estudio: Prognostic_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Obstet Gynecol Surv Año: 1994 Tipo del documento: Article Pais de publicación: Estados Unidos

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