Dimerization and membrane anchors in extracellular targeting of vancomycin group antibiotics.
Antimicrob Agents Chemother
; 39(3): 781-5, 1995 Mar.
Article
en En
| MEDLINE
| ID: mdl-7793894
Antibiotics of the vancomycin group are shown to enhance their affinities for the bacterial cell wall by the devices of either dimerization (vancomycin and other glycopeptides which dimerize even more strongly) or use of a membrane anchor (teicoplanin); a chelate mechanism is suggested in both cases, as supported by antagonism experiments with the cell wall analog di-N-acetyl-L-Lys-D-Ala-D-Ala. These results may have implications for other binding processes which occur near membrane surfaces.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vancomicina
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
1995
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
Estados Unidos