In vitro activity of A-86719.1, a novel 2-pyridone antimicrobial agent.

Eliopoulos, G M; Wennersten, C B; Cole, G; Chu, D; Pizzuti, D; Moellering, R C

Eliopoulos, G M; Wennersten, C B; Cole, G; Chu, D; Pizzuti, D; Moellering, R C.

Afiliación

Eliopoulos GM; Department of Medicine, Deaconess Hospital, Boston, Massachusetts 02215, USA.

Antimicrob Agents Chemother ; 39(4): 850-3, 1995 Apr.

Article en En | MEDLINE | ID: mdl-7785983

RESUMEN

This study evaluated the in vitro activity of A-86719.1, a novel 2-pyridone antimicrobial agent. The drug inhibited all tested members of the family Enterobacteriaceae at < or = 0.5 microgram/ml and all tested Pseudomonas aeruginosa, Burkholderia (Pseudomonas) cepacia, and Xanthomonas maltophilia strains at < or = 2 micrograms/ml. All but two strains of gram-positive bacteria were inhibited by < or = 1 microgram of the new drug per ml, including isolates highly resistant to ciprofloxacin.

Asunto(s)

Antibacterianos/farmacología; Piridonas/farmacología; Quinolizinas/farmacología; Bacterias/efectos de los fármacos; Farmacorresistencia Microbiana; Pruebas de Sensibilidad Microbiana

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piridonas / Quinolizinas / Antibacterianos Idioma: En Revista: Antimicrob Agents Chemother Año: 1995 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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