[DNA ploidy of tumor cells in prognostication of the course of malignant neoformations]. / Ploidnost' DNK opukholevykh kletok v prognozirovanii techeniia zlokachestvennykh novoobrazovanii.
Vestn Ross Akad Med Nauk
; (4): 45-50, 1995.
Article
en Ru
| MEDLINE
| ID: mdl-7780342
DNA flow cytometry (FCM) was used for the clinical prognosis in patients undergone surgical removal of a tumor. The relationship between the structure of the tumor cell population (ploidy) and the frequency, time of a relapse onset (recurrence, metastasis), and the survival length were analyzed. All the patients had presurgical treatment (chemo- and/or radiotherapy). The patients were followed up for 5 to 9 years after surgery. The groups under study included 177 cases of breast cancer, 81 cases of larynx cancer, and 62 cases of colon cancer. Among the patients, the onset of a relapse was earlier and occurred more frequently in cases of aneuploid tumors among the patients regardless of the tumor type. In patients with aneuploid tumors, the most unfavorable prognosis was inherent in the hyperdiploid and multiclonal ones. The probability of 5-year survival for patients with aneuploid tumors appeared to be 20-30% lower than that in cases of diploid ones.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ploidias
/
Neoplasias de la Mama
/
ADN de Neoplasias
/
Neoplasias Laríngeas
/
Neoplasias del Colon
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ru
Revista:
Vestn Ross Akad Med Nauk
Asunto de la revista:
MEDICINA
Año:
1995
Tipo del documento:
Article
Pais de publicación:
Rusia