Constituents of Werneria ciliolata and their in vitro anti-HIV activity.

Piacente, S; Aquino, R; De Tommasi, N; Pizza, C; Lock De Ugaz, O; Chavez Orellana, H; Mahmood, N

Piacente, S; Aquino, R; De Tommasi, N; Pizza, C; Lock De Ugaz, O; Chavez Orellana, H; Mahmood, N.

Afiliación

Piacente S; Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Italy.

Phytochemistry ; 36(4): 991-6, 1994 Jul.

Article en En | MEDLINE | ID: mdl-7765214

RESUMEN

The aerial part of Werneria ciliolata afforded a series of new diterpenes: two ent-kaurane derivatives, a norkaurane, an ent-manoyloxide derivative, a dimeric diterpene, as well as a rare diterpene. Their structures were elucidated by spectroscopic methods, including the concerted application of 1D NMR techniques (DEPT and NOEDS) and 2D NMR techniques (1H-1H COSY and HETCOR). In addition, four known kauranes, four coumarins and 6-hydroxytremetone were isolated. All isolated compounds from W. ciliolata and W. dactylophylla were tested in vitro for anti-viral activity against HIV-1, but only 6-hydroxytremetone showed a significant anti-HIV-1 activity.

Asunto(s)

Antivirales/aislamiento & purificación; VIH-1/efectos de los fármacos; Extractos Vegetales/aislamiento & purificación; Plantas/química; Antivirales/química; Antivirales/farmacología; Línea Celular Transformada; Espectroscopía de Resonancia Magnética; Estructura Molecular; Extractos Vegetales/química; Extractos Vegetales/farmacología; Espectrometría de Masa Bombardeada por Átomos Veloces

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Plantas / Extractos Vegetales / VIH-1 Idioma: En Revista: Phytochemistry Año: 1994 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

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