The effect of removing external sodium upon the cholinergic regulation of potassium permeability in the rat submandibular gland in vitro.

Pediani, J D; McEwan, P E; Elder, H Y; Wilson, S M

Pediani, J D; McEwan, P E; Elder, H Y; Wilson, S M.

Afiliación

Pediani JD; Institute of Physiology, University of Glasgow, U.K.

Comp Biochem Physiol Pharmacol Toxicol Endocrinol ; 107(2): 283-8, 1994 Feb.

Article en En | MEDLINE | ID: mdl-7749595

RESUMEN

Fragments of rat submandibular gland were loaded with 86Rb+ and superfused so that the rate of 86Rb(+)-efflux could be quantified as an indicator of potassium permeability. Acetylcholine evoked an increase in permeability consisting of a transient, calcium-independent response and a sustained, calcium-dependent. Total removal of external sodium significantly inhibited both phases of this response. The results thus confirm that the cholinergic regulation of potassium permeability is compromised by removal of external sodium but do not support the view that this is due, exclusively, to an effect on calcium influx.

Asunto(s)

Sistema Nervioso Parasimpático/fisiología; Potasio/metabolismo; Sodio/fisiología; Glándula Submandibular/metabolismo; Acetilcolina/farmacología; Animales; Radioisótopos de Calcio; Medios de Cultivo; Técnicas In Vitro; Sistema Nervioso Parasimpático/efectos de los fármacos; Ratas; Ratas Wistar; Radioisótopos de Rubidio; Glándula Submandibular/inervación

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Nervioso Parasimpático / Potasio / Sodio / Glándula Submandibular Límite: Animals Idioma: En Revista: Comp Biochem Physiol Pharmacol Toxicol Endocrinol Asunto de la revista: ENDOCRINOLOGIA / FARMACOLOGIA / TOXICOLOGIA Año: 1994 Tipo del documento: Article Pais de publicación: Reino Unido

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