Pharmacokinetics of irinotecan and its metabolites in human blood, bile, and urine.
Cancer Chemother Pharmacol
; 36(1): 79-82, 1995.
Article
en En
| MEDLINE
| ID: mdl-7720181
Two patients were treated with CPT-11 for colorectal cancer and had a percutaneous biliary catheter for extrahepatic biliary obstruction. The first patient was treated with CPT-11 according to the 100-mg/m2 weekly therapeutic schedule, and the second patient was treated every 3 weeks, with a dose of 350 mg/m2 being given at the first course, after which it was decreased to 300 mg/m2 for the following courses. In plasma, the active identified metabolite of CPT-11, SN-38, occurred mainly in the form of a glucuronide conjugate. CPT-11 was mainly excreted in bile and urine as CPT-11. The cumulative biliary and urinary excretion of CPT-11 and its metabolites (SN-38 and SN-38 glucuronide conjugate) over a period of up to 48 h ranged from 25% (100 mg/m2 weekly) to 50% (300 mg/m2 every 3 weeks). This means that CPT-11 can be excreted under other, not yet identified metabolite forms.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Camptotecina
/
Antineoplásicos Fitogénicos
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Chemother Pharmacol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Alemania