Galanin-induced growth hormone secretion in conscious rats: evidence for a possible involvement of somatostatin.

Tanoh, T; Shimatsu, A; Ishikawa, Y; Ihara, C; Yanaihara, N; Imura, H

Tanoh, T; Shimatsu, A; Ishikawa, Y; Ihara, C; Yanaihara, N; Imura, H.

Afiliación

Tanoh T; Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan.

J Neuroendocrinol ; 5(2): 183-7, 1993 Apr.

Article en En | MEDLINE | ID: mdl-7683557

RESUMEN

Intracerebroventricular administration of galanin (GAL) potently evoked growth hormone (GH) secretion in conscious male rats. Pretreatments with neostigmine and cysteamine blunted the GAL-induced GH secretion. Pretreatment of animals with a specific anti-somatostatin serum significantly inhibited the GAL-induced GH secretion. On the contrary, GH-releasing hormone-induced GH secretion was significantly enhanced with cysteamine and anti-somatostatin serum. These results suggest that somatostatin is involved in GAL-induced GH secretion in rats.

Asunto(s)

Hormona del Crecimiento/metabolismo; Péptidos/farmacología; Somatostatina/fisiología; Animales; Cisteamina/farmacología; Galanina; Inyecciones Intraventriculares; Masculino; Neostigmina/farmacología; Péptidos/administración & dosificación; Péptidos/antagonistas & inhibidores; Ratas; Ratas Wistar

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Somatostatina / Hormona del Crecimiento Límite: Animals Idioma: En Revista: J Neuroendocrinol Asunto de la revista: ENDOCRINOLOGIA / NEUROLOGIA Año: 1993 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

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