Brain death diagnosed by forensic analysis of drug distribution in human tissues.
Nihon Hoigaku Zasshi
; 49(3): 169-74, 1995 Jun.
Article
en En
| MEDLINE
| ID: mdl-7674556
Brain death was diagnosed by analyzing drug distribution in human tissues. Concentrations of diazepam and phenobarbital in human tissues, administered therapeutically to 3 patients in a critical condition, were determined by gas chromatography with a nitrogen phosphorus detector and gas chromatography-mass spectrometry. In 2 patients administered drugs while the brain was functioning, drug concentrations in the brain were high compared with those in the other tissues. In the other patient given the drugs after vital signs of the brain ceased, the level of drugs in the brain was much lower than seen in other tissues. We propose that a forensic diagnosis of patients who are brain dead can be made by comparing the concentrations of drugs in the brain given at the time of critical condition with concentration of these agents in other tissues. When cerebral function ceased can be roughly estimated by the variable distribution patterns of drugs and time of administration of these drugs.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fenobarbital
/
Encéfalo
/
Muerte Encefálica
/
Diazepam
/
Medicina Legal
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Nihon Hoigaku Zasshi
Año:
1995
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
Japón