Insulin attenuates alpha-adrenergic aortic contraction in normotensive but not borderline hypertensive rats.
Clin Exp Hypertens
; 17(5): 787-801, 1995 Jul.
Article
en En
| MEDLINE
| ID: mdl-7655448
Hyperinsulinemia can alter vasoconstrictor responses in normotensive and hypertensive rats, but the effects of insulin on vascular contraction have not been evaluated in borderline hypertension. This study determined the effects of insulin on alpha-adrenoceptor mediated aortic contraction in male and female borderline hypertensive rats (BHR) and normotensive Wistar Kyoto (WKY) rats. Dose-response curves to norepinephrine (NE) and phenylephrine (PE) were performed in thoracic aorta in the absence or presence of insulin (100 microU/ml) for 2 hrs. Contraction to NE and PE was reduced in aorta from female WKY rats incubated with insulin compared to control. In aorta from 6 of 13 male WKY rats (insulin responders), an attenuated response to NE and PE was observed in the presence of insulin. However, insulin did not alter responses to NE or PE in aorta from male or female BHR. These results indicate that insulin impairs alpha-adrenoceptor mediated contraction in the normotensive female WKY rat and in a group of responder male WKY rats, but not in BHR. This study supports the presence of a resistance to the vascular effects of insulin in BHR.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vasoconstricción
/
Receptores Adrenérgicos alfa
/
Hipertensión
/
Insulina
Límite:
Animals
Idioma:
En
Revista:
Clin Exp Hypertens
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido