Outcome of infection with different strains of Trypanosoma cruzi in mice lacking CD4 and/or CD8.
Immunol Lett
; 45(1-2): 53-60, 1995 Feb.
Article
en En
| MEDLINE
| ID: mdl-7622189
Mice lacking CD4 and/or CD8 gene expression, generated by embryonic stem-cell technology, were used to study the role of CD4+ and CD8+ cells in the resistance to the acute infection with virulent (Tulahuén and RA) or mild (CA-I) strains of Trypanosoma cruzi. The presence of both CD4+ and CD8+ cells contributed to the survival of mice infected with T. cruzi, and each T-cell subtype was able to sustain protective functions in the absence of the other one. However, in certain host-parasite combinations, CD8+ cell-independent mechanisms were able to control the parasite load. Moreover, CD8- mice chronically infected with a low virulent strain of T. cruzi were protected from an otherwise lethal challenge with the parasite. A different organ distribution of parasite nests was observed when mutant (but not wild type) animals infected with different parasite strains were compared. CD4- mice produced high levels of IgG antibodies against peptide antigens or a whole homogenate from the parasite after infection with CA-I strain. A dramatic enhancement of IgG1- and IgG2a-specific antibodies was observed.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trypanosoma cruzi
/
Linfocitos T CD4-Positivos
/
Antígenos CD4
/
Antígenos CD8
/
Enfermedad de Chagas
/
Linfocitos T CD8-positivos
/
Síndromes de Inmunodeficiencia
/
Antígenos de Protozoos
Límite:
Animals
Idioma:
En
Revista:
Immunol Lett
Año:
1995
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
Países Bajos