Hormonal oral contraceptives, urinary porphyrin excretion and porphyrias.
Horm Metab Res
; 27(8): 379-83, 1995 Aug.
Article
en En
| MEDLINE
| ID: mdl-7590628
ABSTRACT
PIP: At clinics in Marburg and Berlin, Germany, physicians conducted a double-blind study to elucidate the effectiveness of two low-dose hormonal contraceptives on parameters of heme-biosynthesis in urine. After a menstrual cycle without exogenous hormones (cycle 0), 40 healthy women took an oral contraceptive (OC) containing either 75 mcg gestodene and 30 mcg ethinyl estradiol daily (EE2) for 21 days or 150 mcg desogestrel and 30 mcg EE2. They took no hormones for the first seven days of the next cycle. They used the OCs for six cycles. In all cases, porphyrin precursors delta-aminolevulinic acid and porphobilinogen and the mean of uroporphyrin and coproporphyrin fell within normal parameters. Only one woman developed mild secondary porphyrinuria without clinical or pathological significance. The coproporphyrin isomer I was moderately higher than the normal range (17-31% vs. 32% at cycle 0 and 43% at cycle 6) and isomer III was moderately lower (69-83% vs. 68% and 57%, respectively). Three women had repeated premenstrual symptoms of an acute hepatic porphyria (acute intermittent porphyria and hereditary coproporphyria). Treatment with the OCs successfully stabilized the latent phase of premenstrual forms of acute hepatic porphyrias. This study demonstrates that low-dose OCs do not affect urinary porphyrin excretion.
Palabras clave
Biology; Contraception; Contraceptive Agents; Contraceptive Agents, Female; Contraceptive Agents, Progestin; Contraceptive Methods; Dermatitis; Desogestrel; Developed Countries; Diseases; Double-blind Studies; Europe; Family Planning; Germany; Gestodene; Hepatic Effects; Menstruation Disorders; Oral Contraceptives; Oral Contraceptives, Combined; Physiology; Porphyria; Premenstrual Tension; Research Methodology; Research Report; Studies; Treatment; Western Europe
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Porfirias
/
Porfirinas
/
Anticonceptivos Orales Combinados
/
Anticonceptivos Hormonales Orales
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Horm Metab Res
Año:
1995
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Alemania