Treatment with acarbose, an alpha-glucosidase inhibitor, reduces increased albumin excretion in streptozotocin-diabetic rats.

Cohen, M P; Vasselli, J R; Neuman, R G; Witt, J

Cohen, M P; Vasselli, J R; Neuman, R G; Witt, J.

Afiliación

Cohen MP; Institute for Metabolic Research, University City Science Center, Philadelphia, PA, USA.

Gen Pharmacol ; 26(6): 1355-61, 1995 Oct.

Article en En | MEDLINE | ID: mdl-7590131

RESUMEN

1. We examined the effect of the alpha-glucosidase inhibitor acarbose on urinary albumin excretion (UAE) in streptozotocin diabetic rats. 2. Treatment with acarbose for 8 weeks after induction of diabetes prevented the significant increase in UAE observed in untreated diabetic rats relative to nondiabetic controls. 3. Acarbose significantly reduced integrated glycemia, which correlated with albumin excretion rates, and exerts a salutary effect on diabetic renal dysfunction.

Asunto(s)

Inhibidores Enzimáticos/farmacología; Glucosidasas/efectos de los fármacos; Trisacáridos/uso terapéutico; Acarbosa; Albuminuria; Animales; Glucemia/metabolismo; Diabetes Mellitus Experimental; Modelos Animales de Enfermedad; Masculino; Ratas; Ratas Wistar; Estreptozocina/farmacología; Factores de Tiempo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trisacáridos / Inhibidores Enzimáticos / Glucosidasas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Gen Pharmacol Año: 1995 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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