Nicotinic acetylcholine receptors on capsaicin-sensitive nerves.
Neuroreport
; 6(11): 1578-82, 1995 Jul 31.
Article
en En
| MEDLINE
| ID: mdl-7579153
To study the density of nicotinic acetylcholine receptors on primary afferents and central nociceptive pathways, [3H](-)-nicotine binding was conducted in the cerebral cortex and spinal cord including dorsal roots and ganglia (DRG), of control rats and rats desensitized by neonatal capsaicin treatment. [3H](-)-nicotine binding in capsaicin-treated rats was reduced in cerebral cortex by 35% and spinal cord+DRG by 46% (p < 0.05). Functionally, both iontophoretically applied acetylcholine- and capsaicin-evoked flares (measured by laser Doppler flowmetry) were reduced in capsaicin-treated animals (p < 0.05); similarly, electrical stimulation-evoked flares were significantly lower in the same group, compared with controls (p < 0.05). These data provide direct evidence that many neuronal nicotinic acetylcholine receptors are associated with capsaicin-sensitive peptidergic neurones, including primary afferents, DRG and central nociceptive pathways.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dolor
/
Médula Espinal
/
Capsaicina
/
Corteza Cerebral
/
Receptores Nicotínicos
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Neuroreport
Asunto de la revista:
NEUROLOGIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Reino Unido