Diagnostic and prognostic significance of anticardiolipin antibodies in patients with recurrent spontaneous abortions.
Am J Reprod Immunol
; 33(3): 228-33, 1995 Mar.
Article
en En
| MEDLINE
| ID: mdl-7546239
PROBLEM: The role of ACA in unexplained RSA is controversial. In the present study, diagnostic and prognostic aspects were investigated. METHOD: One hundred five nonpregnant patients with primary, 29 with secondary RSA, and 209 controls were investigated for IgG-ACA. Follow-up studies were done during pregnancy in 76 individuals. IgM-ACA were tested in a subset of patients. RESULTS: Elevated ACA levels were significantly more frequent in both patient groups (26 and 24%) than in controls (16%). However, there was no correlation of ACA with various parameters including pregnancy outcome. In ACA-positive patients with successful pregnancy a significant decrease of ACA values during pregnancy was observed, while ACA remained high in aborting patients. IgG- and IgM-ACA correlated well. CONCLUSIONS: Although the data from nonpregnant RSA patients does not allow diagnostic or prognostic conclusions to be drawn, sequential testing of ACA-positive individuals provides the possibility to foresee pregnancy outcome.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aborto Habitual
/
Anticuerpos Anticardiolipina
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Am J Reprod Immunol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Dinamarca