Hepatitis B and D genomes in hepatitis B surface antigen negative patients with chronic hepatitis C.
J Med Virol
; 45(2): 168-73, 1995 Feb.
Article
en En
| MEDLINE
| ID: mdl-7539829
Hepatitis B and hepatitis D viral genomes were tested by nested polymerase chain reaction in the serum and liver of 69 hepatitis B surface antigen (HBsAg) negative, anti-hepatitis C virus (HCV) positive patients (47 with HCV RNA and 22 without HCV RNA). Serum hepatitis B virus (HBV) DNA-was detected in 49% of the patients with HCV-RNA and in 64% of those without HCV-RNA. Furthermore, intrahepatic HBV-DNA was found in four of five (80%) of the biopsies analysed. Delta genome was found in 72% and 73%, respectively, of the anti-HCV positive patients with or without HCV-RNA. In addition, intrahepatic delta virus genome was detected in another four liver biopsies studied. In the group of patients with HCV-RNA, the simultaneous presence of hepatitis B and D genomes was statistically higher in transfused patients than in drug addicts, or in those with an unknown infection route (P < 0.001). These results show a high percentage of B and D genomes in HBsAg negative patients with anti-HCV, irrespective of the presence or absence of the HCV genome. However, the clinical implications of this finding should be examined in future studies.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Virus de la Hepatitis Delta
/
Virus de la Hepatitis B
/
Hepatitis C
/
Hepatitis Crónica
Límite:
Humans
/
Male
Idioma:
En
Revista:
J Med Virol
Año:
1995
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Estados Unidos